Influence of fluorine atom on certain pharmaceutical properties of flufenamic acid

The purpose of the present study was to investigate the effect of fluorine atom on certain pharmaceutical properties of flufenamic acid [F] using mefenamic acid [M] as a control. Both drugs have been anthranilic acid derivatives with 3 fluorine atoms in the former. The pharmaceutical properties studied were flowability [angle of repose], bulk density, porosity, and wettability [sinking time]. Dissolution and release studies of both drugs from capsules and ointment bases were also carried out